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Literature summary for 2.3.1.137 extracted from
- Properties of purified carnitine acyltransferases of mouse liver peroxisomes (1984), J. Biol. Chem., 259, 13089-13095.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoate) | retains its maximum activity when preincubated at pH 7.0 or 8.5 | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-carnitine | - |
Mus musculus | |
| D-carnitine | - |
Rattus norvegicus | |
| Trypsin | - |
Mus musculus | |
| Zn2+ | inhibits enzyme in reverse direction | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
L-octanoylcarnitine | - |
Mus musculus | |
| 0.104 | - |
L-palmitoylcarnitine | - |
Mus musculus | |
| 0.11 | - |
CoASH | - |
Mus musculus | |
| 0.783 | - |
acetyl-L-carnitine | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| peroxisome | - |
Mus musculus | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
| peroxisome | - |
Bos taurus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
gel filtration | Mus musculus |
| 66000 | - |
- |
Rattus norvegicus |
| 66000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Mus musculus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Bos taurus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Canis lupus familiaris | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Rattus norvegicus Sprague-Dawley | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | Mus musculus | - |
acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | Rattus norvegicus | - |
acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | Bos taurus | - |
acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | Canis lupus familiaris | - |
acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | Rattus norvegicus Sprague-Dawley | - |
acyl-CoA + L-carnitine | - |
r | |
| L-carnitine + octanoyl-CoA | Mus musculus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Rattus norvegicus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Bos taurus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Rattus norvegicus Sprague-Dawley | - |
octanoyl-L-carnitine + CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Rattus norvegicus | - |
L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Bos taurus | - |
L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Mus musculus | reverse reaction | L-carnitine + octanoyl-CoA | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
beef | - |
| Canis lupus familiaris | - |
dog | - |
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | - |
Mus musculus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Bos taurus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Canis lupus familiaris | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus Sprague-Dawley | acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | - |
Mus musculus | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Rattus norvegicus | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Bos taurus | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Canis lupus familiaris | acyl-CoA + L-carnitine | - |
r | |
| acyl-L-carnitine + CoA | - |
Rattus norvegicus Sprague-Dawley | acyl-CoA + L-carnitine | - |
r | |
| CoA + L-octanoylcarnitine | - |
Mus musculus | octanoyl-CoA + L-carnitine | - |
? | |
| CoA + L-palmitoylcarnitine | - |
Mus musculus | palmitoyl-CoA + L-carnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Mus musculus | CoA + L-hexanoylcarnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-hexanoylcarnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-hexanoylcarnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Rattus norvegicus Sprague-Dawley | CoA + L-hexanoylcarnitine | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Mus musculus | octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Rattus norvegicus | octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Bos taurus | octanoyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Rattus norvegicus Sprague-Dawley | octanoyl-L-carnitine + CoA | - |
r | |
| L-hexanoylcarnitine + CoA | - |
Mus musculus | hexanoyl-CoA + L-carnitine | - |
r | |
| L-hexanoylcarnitine + CoA | - |
Rattus norvegicus | hexanoyl-CoA + L-carnitine | - |
r | |
| L-hexanoylcarnitine + CoA | - |
Bos taurus | hexanoyl-CoA + L-carnitine | - |
r | |
| L-hexanoylcarnitine + CoA | - |
Rattus norvegicus Sprague-Dawley | hexanoyl-CoA + L-carnitine | - |
r | |
| additional information | malonyl-CoA is not a substrate | Mus musculus | ? | - |
? | |
| octanoyl-L-carnitine + CoA | - |
Rattus norvegicus | L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | - |
Bos taurus | L-carnitine + octanoyl-CoA | - |
r | |
| octanoyl-L-carnitine + CoA | reverse reaction | Mus musculus | L-carnitine + octanoyl-CoA | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Mus musculus |
| COT | - |
Rattus norvegicus |
| COT | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Mus musculus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10 | - |
Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.84 | - |
D-carnitine | - |
Mus musculus | |
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