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Literature summary for 2.3.1.137 extracted from
- Selective modulation of carnitine long-chain acyltransferase activities: Kinetics, inhibitors, and active sites of COT and CPT-II (1999), Adv. Exp. Med. Biol., 466, 103-109.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hemiacylcarnitinium | - |
Bos taurus |  |
| hemicholinium | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.34 | - |
decanoyl-CoA | - |
Bos taurus | |
| 7.4 | - |
palmitoyl-L-carnitine | - |
Bos taurus | |
| 8.4 | - |
Decanoyl-L-carnitine | - |
Bos taurus | |
| 16 | - |
acetyl-CoA | - |
Bos taurus | |
| 108 | - |
L-carnitine | - |
Bos taurus | |
| 143 | - |
choline | mutant [Asn505]COT | Bos taurus | |
| 160 | - |
L-carnitine | mutant [Asn505]COT | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Bos taurus | 5783 | - |
| peroxisome | - |
Bos taurus | 5777 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Bos taurus | - |
acyl-L-carnitine + CoA | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
beef | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + L-carnitine | - |
Bos taurus | CoA + acetyl-carnitine | - |
? | |
| acyl-CoA + L-carnitine | - |
Bos taurus | acyl-L-carnitine + CoA | - |
r | |
| choline + L-carnitine | - |
Bos taurus | ? | - |
? | |
| decanoyl-L-carnitine + CoA | - |
Bos taurus | decanoyl-CoA + L-carnitine | - |
? | |
| palmitoyl-L-carnitine + CoA | - |
Bos taurus | palmitoyl-CoA + L-carnitine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Bos taurus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 113 | - |
hemiacylcarnitinium | - |
Bos taurus | |
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