Literature summary for 2.3.1.137 extracted from

Morillas, M.; Gomez-Puertas, P.; Bentebibel, A.; Selles, E.; Casals, N.; Valencia, A.; Hegardt, F.G.; Asins, G.; Serra, D.
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition (2003), J. Biol. Chem., 278, 9058-9063.

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Inhibitors

Inhibitors	Comment	Organism	Structure
malonyl-CoA	regulatory role, enzyme belongs to the group of malonyl-CoA inhibitable carnitine acyltransferases with highly conserved residues being involved in the inhibition, i.e. Thr314, Asn464, Ala478, Met593, and Cys608, amino acid sequence comparison with enzymes from other species	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
octanoyl-CoA + L-carnitine	Rattus norvegicus	-	CoA + L-octanoylcarnitine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
octanoyl-CoA + L-carnitine	-	Rattus norvegicus	CoA + L-octanoylcarnitine	-	?

Synonyms

Synonyms	Comment	Organism
carnitine octanoyltransferase	-	Rattus norvegicus
COT	-	Rattus norvegicus

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Release 2023.1 (January 2023)