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Literature summary for 2.3.1.147 extracted from

  • Winkler, J.D.; Sung, C.M.; Chabot-Flecher, M.; Griswold, D.E.; Marshall, L.A.; Chilton, F.H.; Bondinell, W.; Mayer, R.J.
    beta-Lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase (1998), Mol. Pharmacol., 53, 322-329.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3S,4R)-[4-(Isobutenyloxy)-3-triphenylmethylamino]azetitin-2-one i.e. SB 216754 Homo sapiens
4-methoxybenzyl(3S,4R)-6-bromo-6-[(1-methyl-1,2,3-triazol-4-yl)-hydroxymethyl]penicillanate i.e. SB 212047 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is important for the production of inflammatory lipid mediators in stimulated cells ?
-
?
additional information Homo sapiens the enzyme is the key mediator of arachidonate remodeling ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine formation of an acyl-enzyme intermediate Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
monocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is important for the production of inflammatory lipid mediators in stimulated cells Homo sapiens ?
-
?
additional information the enzyme is the key mediator of arachidonate remodeling Homo sapiens ?
-
?