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Literature summary for 2.3.1.150 extracted from

  • Wijekoon, C.P.; Facchini, P.J.
    Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing (2012), Plant J., 69, 1052-1063.
    View publication on PubMed
Search for more literature for 2.3.1.150

Cloned(Commentary)

Cloned (Comment) Organism
real-time quantitative PCR expression analysis Papaver somniferum

Protein Variants

Protein Variants Comment Organism
additional information specific gene silencing of the enzymes involved in alkaloid biosynthesis in opium poppy using virus-induced gene silencing, VIGS, and Agrobacterium tumefaciens transfection Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + salutaridinol Papaver somniferum
-
 CoA + 7-O-acetylsalutaridinol
-
 ?

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + salutaridinol
-
 Papaver somniferum CoA + 7-O-acetylsalutaridinol
-
 ?

Synonyms

Synonyms Comment Organism
SalAT
-
 Papaver somniferum
salutaridine 7-O-acetyltransferase
-
 Papaver somniferum

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA dependent on Papaver somniferum

General Information

General Information Comment Organism
malfunction silencing of the gene encoding SalAT results in the accumulation of salutaridine, which is not the corresponding enzymatic substrate. Reduction of SalAt transcript and protein levels results in an increase in salutaridine, i.e. an approximately 20-fold increase compared with controls, and a concomitant decrease in thebaine levels. Codeine and morphine accumulation are also significantly reduced Papaver somniferum
metabolism SalAT is involved in the benzylisoquinoline alkaloid biosynthesis in opium poppy from (R)-reticuline to morphine, pathway overview Papaver somniferum