Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isobutyryl-CoA + 3 malonyl-CoA | Humulus lupulus | - |
phloroisobutyrophenone + 3 CO2 + 4 CoA | phloroglucinol derivative, intermediates in the biosynthesis of the hop bitter alpha- and beta-acids | ? | |
isovaleryl-CoA + malonyl-CoA | Humulus lupulus | - |
phloroisovalerophenone + CO2 + CoA | phloroglucinol derivative, intermediates in the biosynthesis of the hop bitter alpha- and beta-acids | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Humulus lupulus | - |
hop | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
isovaleryl-CoA + 3 malonyl-CoA = 4 CoA + 3 CO2 + phlorisovalerophenone | Closely related to EC 2.3.1.74, chalcone synthase. The product, 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one, is chloroisovalerophenone. Also acts on isobutyryl-CoA as substrate to give phlorisobutyrophenone. The products are intermediates in the biosynthesis of the bitter alpha-acids in hops, Humulus lupulus | Humulus lupulus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isobutyryl-CoA + 3 malonyl-CoA | - |
Humulus lupulus | phloroisobutyrophenone + 3 CO2 + 4 CoA | - |
? | |
isobutyryl-CoA + 3 malonyl-CoA | - |
Humulus lupulus | phloroisobutyrophenone + 3 CO2 + 4 CoA | phloroglucinol derivative, intermediates in the biosynthesis of the hop bitter alpha- and beta-acids | ? | |
isovaleryl-CoA + malonyl-CoA | - |
Humulus lupulus | phloroisovalerophenone + CO2 + CoA | - |
? | |
isovaleryl-CoA + malonyl-CoA | - |
Humulus lupulus | phloroisovalerophenone + CO2 + CoA | phloroglucinol derivative, intermediates in the biosynthesis of the hop bitter alpha- and beta-acids | ? |
Synonyms | Comment | Organism |
---|---|---|
VPS | - |
Humulus lupulus |