Crystallization (Comment) | Organism |
---|---|
purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM TrisHCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis | Streptococcus pneumoniae |
purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 1922% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | - |
Escherichia coli | |
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | - |
Haemophilus influenzae | |
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | - |
Staphylococcus aureus | |
(2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | - |
Streptococcus pneumoniae | |
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | - |
Escherichia coli | |
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | - |
Haemophilus influenzae | |
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | - |
Staphylococcus aureus | |
1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | - |
Streptococcus pneumoniae | |
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | - |
Escherichia coli | |
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | - |
Haemophilus influenzae | |
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | - |
Staphylococcus aureus | |
2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | - |
Streptococcus pneumoniae | |
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | - |
Escherichia coli | |
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | - |
Haemophilus influenzae | |
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | - |
Staphylococcus aureus | |
2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | - |
Streptococcus pneumoniae | |
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | - |
Escherichia coli | |
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | - |
Haemophilus influenzae | |
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | - |
Staphylococcus aureus | |
4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | - |
Streptococcus pneumoniae | |
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | - |
Escherichia coli | |
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | - |
Haemophilus influenzae | |
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | - |
Staphylococcus aureus | |
4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | - |
Streptococcus pneumoniae | |
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | - |
Escherichia coli | |
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | - |
Haemophilus influenzae | |
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | - |
Staphylococcus aureus | |
4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | - |
Streptococcus pneumoniae | |
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | - |
Escherichia coli | |
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | - |
Haemophilus influenzae | |
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | - |
Staphylococcus aureus | |
4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | - |
Streptococcus pneumoniae | |
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Escherichia coli | |
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Haemophilus influenzae | |
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Staphylococcus aureus | |
4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Streptococcus pneumoniae | |
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Escherichia coli | |
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Haemophilus influenzae | |
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Staphylococcus aureus | |
4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | - |
Streptococcus pneumoniae | |
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | - |
Escherichia coli | |
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | - |
Haemophilus influenzae | |
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | - |
Staphylococcus aureus | |
methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | - |
Streptococcus pneumoniae | |
additional information | high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series | Escherichia coli | |
additional information | high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series | Haemophilus influenzae | |
additional information | high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series | Staphylococcus aureus | |
additional information | high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series | Streptococcus pneumoniae | |
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | - |
Escherichia coli | |
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | - |
Haemophilus influenzae | |
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | - |
Staphylococcus aureus | |
N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | - |
Streptococcus pneumoniae | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | - |
Escherichia coli | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | - |
Haemophilus influenzae | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | - |
Staphylococcus aureus | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | - |
Streptococcus pneumoniae | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | - |
Escherichia coli | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | - |
Haemophilus influenzae | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | - |
Staphylococcus aureus | |
N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer | Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer | Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer | Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer | Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | - |
Escherichia coli | |
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | - |
Haemophilus influenzae | |
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | - |
Staphylococcus aureus | |
N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Escherichia coli | |
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Haemophilus influenzae | |
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Staphylococcus aureus | |
N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | - |
Streptococcus pneumoniae | |
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | - |
Escherichia coli | |
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | - |
Haemophilus influenzae | |
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | - |
Staphylococcus aureus | |
[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | - |
Streptococcus pneumoniae | |
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | - |
Escherichia coli | |
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | - |
Haemophilus influenzae | |
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | - |
Staphylococcus aureus | |
[[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | - |
Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + alpha-D-glucosamine 1-phosphate | Staphylococcus aureus | - |
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | Haemophilus influenzae | - |
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | Escherichia coli | - |
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | Streptococcus pneumoniae | - |
CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + alpha-D-glucosamine 1-phosphate | - |
Staphylococcus aureus | CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | - |
Haemophilus influenzae | CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | - |
Escherichia coli | CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? | |
acetyl-CoA + alpha-D-glucosamine 1-phosphate | - |
Streptococcus pneumoniae | CoA + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterotrimer | - |
Staphylococcus aureus |
heterotrimer | - |
Haemophilus influenzae |
heterotrimer | - |
Escherichia coli |
heterotrimer | - |
Streptococcus pneumoniae |
Synonyms | Comment | Organism |
---|---|---|
GlmU | - |
Staphylococcus aureus |
GlmU | - |
Haemophilus influenzae |
GlmU | - |
Escherichia coli |
GlmU | - |
Streptococcus pneumoniae |
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase | - |
Staphylococcus aureus |
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase | - |
Haemophilus influenzae |
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase | - |
Escherichia coli |
N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase | - |
Streptococcus pneumoniae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at romm temperature | Staphylococcus aureus |
22 | - |
assay at romm temperature | Haemophilus influenzae |
22 | - |
assay at romm temperature | Escherichia coli |
22 | - |
assay at romm temperature | Streptococcus pneumoniae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | 7.4 | assay at | Staphylococcus aureus |
7.3 | 7.4 | assay at | Haemophilus influenzae |
7.3 | 7.4 | assay at | Escherichia coli |
7.3 | 7.4 | assay at | Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | - |
pH 7.35, 22°C | Escherichia coli | 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | |
0.0001 | - |
pH 7.35, 22°C | Escherichia coli | [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | |
0.0002 | - |
pH 7.35, 22°C | Haemophilus influenzae | [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | |
0.0002 | - |
pH 7.35, 22°C | Escherichia coli | [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | |
0.00025 | - |
pH 7.35, 22°C | Escherichia coli | 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | |
0.0003 | - |
pH 7.35, 22°C | Haemophilus influenzae | [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | |
0.0004 | - |
pH 7.35, 22°C | Escherichia coli | 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.0005 | - |
pH 7.35, 22°C | Escherichia coli | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | |
0.0005 | - |
pH 7.35, 22°C | Escherichia coli | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | |
0.0005 | - |
pH 7.35, 22°C | Escherichia coli | (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | |
0.0005 | - |
pH 7.35, 22°C | Haemophilus influenzae | 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | |
0.0005 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | |
0.0005 | - |
pH 7.35, 22°C | Escherichia coli | 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | |
0.0006 | - |
pH 7.35, 22°C | Haemophilus influenzae | 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | |
0.0009 | - |
pH 7.35, 22°C | Escherichia coli | 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | |
0.001 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | |
0.001 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | |
0.001 | - |
pH 7.35, 22°C | Haemophilus influenzae | 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | |
0.0015 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | |
0.002 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | |
0.002 | - |
pH 7.35, 22°C | Haemophilus influenzae | 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | |
0.002 | - |
pH 7.35, 22°C | Escherichia coli | 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | |
0.002 | - |
pH 7.35, 22°C | Haemophilus influenzae | (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | |
0.002 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | |
0.002 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | |
0.002 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.003 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | |
0.003 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | |
0.003 | - |
pH 7.35, 22°C | Escherichia coli | 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | |
0.003 | - |
pH 7.35, 22°C | Escherichia coli | 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.003 | - |
pH 7.35, 22°C | Haemophilus influenzae | 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.004 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.005 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | |
0.005 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.005 | - |
pH 7.35, 22°C | Haemophilus influenzae | 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | |
0.005 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.005 | - |
pH 7.35, 22°C | Haemophilus influenzae | 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | |
0.006 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | |
0.006 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | |
0.006 | - |
pH 7.35, 22°C | Haemophilus influenzae | 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.008 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | |
0.01 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | |
0.01 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.01 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | |
0.01 | - |
pH 7.35, 22°C | Staphylococcus aureus | 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.012 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | |
0.015 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.015 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.015 | - |
pH 7.35, 22°C | Escherichia coli | methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | |
0.015 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid | |
0.016 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | |
0.017 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.02 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | |
0.02 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | |
0.02 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | |
0.02 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.021 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.025 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.03 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | |
0.03 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.04 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.04 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.047 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.05 | - |
pH 7.35, 22°C | Staphylococcus aureus | 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid | |
0.055 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | |
0.055 | - |
pH 7.35, 22°C | Haemophilus influenzae | methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | |
0.06 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.07 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | |
0.07 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.08 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.08 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | |
0.08 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.09 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | |
0.1 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | |
0.11 | - |
pH 7.35, 22°C | Streptococcus pneumoniae | N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | |
0.12 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | |
0.13 | - |
pH 7.35, 22°C | Escherichia coli | N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Escherichia coli | 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | |
0.2 | - |
above, pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Escherichia coli | N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Haemophilus influenzae | N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Escherichia coli | N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | |
0.2 | - |
above, pH 7.35, 22°C | Streptococcus pneumoniae | methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Escherichia coli | N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid | |
0.2 | - |
above, pH 7.35, 22°C | Staphylococcus aureus | [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid | |
0.2 | - |
pH 7.35, 22°C | Escherichia coli | N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide | |
0.54 | - |
pH 7.35, 22°C | Haemophilus influenzae | N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide |
General Information | Comment | Organism |
---|---|---|
physiological function | the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate | Staphylococcus aureus |
physiological function | the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate | Haemophilus influenzae |
physiological function | the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate | Escherichia coli |
physiological function | the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate | Streptococcus pneumoniae |