Literature summary for 2.3.1.165 extracted from

Child, C.J.; Spencer, J.B.; Bhogal, P.; Shoolingin-Jordan, P.M.
Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies (1996), Biochemistry, 35, 12267-12274.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,3R)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide	0.0014 mM, complete inactivation after 40 min, acetyl-CoA protects	Penicillium griseofulvum
1,3-dibromo-propane-2-one	very rapid inactivation, inactivation half-life: 7 s	Penicillium griseofulvum
5,5'-dithiobis(2-nitrobenzoic acid)	0.01 mM, rapid inactivation, inactivation half-life: approx. 15 s, both acetyl-CoA and malonyl-CoA protect	Penicillium griseofulvum
iodoacetamide	100fold molar excess, complete inactivation after 30 min	Penicillium griseofulvum

Organism

Organism	UniProt	Comment	Textmining
Penicillium griseofulvum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + malonyl-CoA + NADPH	-	Penicillium griseofulvum	6-methylsalicylate + CoA + CO2 + NADP+	-	?

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Release 2023.1 (January 2023)