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Literature summary for 2.3.1.165 extracted from

  • Moriguchi, T.; Ebizuka, Y.; Fujii, I.
    Domain-domain interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus (2008), ChemBioChem, 9, 1207-1212.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Aspergillus terreus

Protein Variants

Protein Variants Comment Organism
C216A mutant without catalytic activity Aspergillus terreus
H939A mutant with catalytic activity Aspergillus terreus
additional information deletion of one of the 6-methylsalicylic acid synthase domains ketosynthase, acyltransferase, dehydratase, ketoreductase, or acyl carrier protein results in a lost of catalytic activity Aspergillus terreus
S1761A mutant without catalytic activity Aspergillus terreus
S667A mutant without catalytic activity Aspergillus terreus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
190000
-
-
Penicillium griseofulvum

Organism

Organism UniProt Comment Textmining
Aspergillus terreus
-
-
-
Penicillium griseofulvum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + malonyl-CoA + NADPH
-
Aspergillus terreus 6-methylsalicylate + CoA + CO2 + NADP+
-
?
acetyl-CoA + malonyl-CoA + NADPH
-
Penicillium griseofulvum 6-methylsalicylate + CoA + CO2 + NADP+
-
?

Subunits

Subunits Comment Organism
homotetramer every subunit of 6-methylsalicylic acid synthase from Aspergillus terreus consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domain, proposed from deletion mutant analyses Aspergillus terreus
More 6-methylsalicylic acid synthase from Penicillium patulum consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domains Penicillium griseofulvum

Synonyms

Synonyms Comment Organism
6-methylsalicylic acid synthase
-
Aspergillus terreus
6-methylsalicylic acid synthase
-
Penicillium griseofulvum
6-MSA
-
Penicillium griseofulvum
ATX 6-methylsalicylic acid synthase from Aspergillus terreus Aspergillus terreus
iPKS 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Aspergillus terreus
iPKS 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Penicillium griseofulvum
iterative type I polyketide synthase 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Aspergillus terreus
iterative type I polyketide synthase 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. Penicillium griseofulvum