Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Penicillium griseofulvum |
Protein Variants | Comment | Organism |
---|---|---|
H958A | mutation in the THID active site | Penicillium griseofulvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium griseofulvum | P22367 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetoacetyl-CoA + 3 malonyl-CoA + NADPH + H+ | - |
Penicillium griseofulvum | 6-methyl triacetic acid lactone + CoA + NADP+ | - |
? | |
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ | - |
Penicillium griseofulvum | 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O | - |
? | |
additional information | no enzymatic dehydration takes place at a triketide stage of 6-MSA assembly, so loss of water must occur at the tetraketide stage. The enzyme is able to accept malonate surrogates of different chain lengths and bearing various functionalities (including alkyne and fluorine moieties) at different positions and for every round of chain extension, and also to generate novel pentaketide products | Penicillium griseofulvum | ? | - |
? |