Any feedback?
Literature summary for 2.3.1.168 extracted from
- Swinging arms and swinging domains in multifunctional emzymes: catalytic machines for multistep reactions (2000), Annu. Rev. Biochem., 69, 961-1004.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acidithiobacillus ferrooxidans | - |
- |
- |
| Azotobacter vinelandii | - |
- |
- |
| Cupriavidus necator | - |
- |
- |
| Enterococcus faecalis | - |
i.e. Enterococcus faecalis | - |
| Escherichia coli | - |
- |
- |
| Geobacillus stearothermophilus | - |
- |
- |
| Haemophilus influenzae | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Neisseria meningitidis | - |
- |
- |
| no activity in archaebacteria | - |
- |
- |
| no activity in Desulfovibrio africanus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Zymomonas mobilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine | enzyme contains 1 lipoyl residue per E2 chain of branched-chain 2-oxo acid dehydrogenase | Homo sapiens | CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine | - |
? |  |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Acidithiobacillus ferrooxidans | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Haemophilus influenzae | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Escherichia coli | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Neisseria meningitidis | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Azotobacter vinelandii | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 3 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Cupriavidus necator | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 1 lipoyl residue per E2 chain of pyruvate dehydrogenase complex | Saccharomyces cerevisiae | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 1 lipoyl residue per E2 chain of pyruvate dehydrogenase complex | Zymomonas mobilis | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Acidithiobacillus ferrooxidans | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Haemophilus influenzae | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Escherichia coli | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Homo sapiens | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Saccharomyces cerevisiae | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Geobacillus stearothermophilus | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Enterococcus faecalis | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Neisseria meningitidis | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Azotobacter vinelandii | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Cupriavidus necator | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | part of the pyruvate dehydrogenase reaction | Zymomonas mobilis | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 2 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Homo sapiens | CoA + S-acetyldihydrolipoamide | - |
? | |
| acetyl-CoA + dihydrolipoamide | enzyme contains 2 lipoyl residues per E2 chain of pyruvate dehydrogenase complex | Enterococcus faecalis | CoA + S-acetyldihydrolipoamide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Acidithiobacillus ferrooxidans |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Escherichia coli |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Homo sapiens |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Geobacillus stearothermophilus |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Enterococcus faecalis |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Azotobacter vinelandii |
| More | lipoyl domains and inner core in the structure of multienzyme complex, overview | Zymomonas mobilis |
| More | C-terminus of E2 is joined to the N-terminus of E3 in the pyruvate dehydrogenase complex, subunit organization | Acidithiobacillus ferrooxidans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme is the E2 component of the multienzyme complex branched-chain alpha-keto acid dehydrogenase, i.e. branched-chain 2-oxo acid dehydrogenase | Homo sapiens |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Acidithiobacillus ferrooxidans |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Haemophilus influenzae |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Escherichia coli |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Saccharomyces cerevisiae |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Geobacillus stearothermophilus |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Enterococcus faecalis |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Neisseria meningitidis |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Azotobacter vinelandii |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Cupriavidus necator |
| More | enzyme is the E2 component of the multienzyme complex pyruvate dehydrogenase | Zymomonas mobilis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
