Literature summary for 2.3.1.177 extracted from

Chizzali, C.; Beerhues, L.
Phytoalexins of the pyrinae: biphenyls and dibenzofurans (2012), Beilstein J. Org. Chem., 8, 613-620.

Search for more literature for 2.3.1.177

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
3 malonyl-CoA + benzoyl-CoA	Malus sylvestris	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Malus domestica	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Chaenomeles japonica	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Pyrus communis	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Rhaphiolepis bibas	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Sorbus aucuparia	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Photinia glabra	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Rhaphiolepis umbellata	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Aronia arbutifolia	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Chaenomeles cathayensis	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	Malus sieversii	-	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Aronia arbutifolia	-	-	-
Chaenomeles cathayensis	-	-	-
Chaenomeles japonica	-	-	-
Malus domestica	-	-	-
Malus sieversii	-	-	-
Malus sylvestris	-	-	-
Photinia glabra	-	-	-
Pyrus communis	-	-	-
Rhaphiolepis bibas	-	-	-
Rhaphiolepis umbellata	-	-	-
Sorbus aucuparia	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cell culture	-	Sorbus aucuparia	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
3 malonyl-CoA + benzoyl-CoA	-	Malus sylvestris	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Malus domestica	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Chaenomeles japonica	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Pyrus communis	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Rhaphiolepis bibas	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Sorbus aucuparia	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Photinia glabra	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Rhaphiolepis umbellata	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Aronia arbutifolia	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Chaenomeles cathayensis	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
3 malonyl-CoA + benzoyl-CoA	-	Malus sieversii	4 CoA + 3,5-dihydroxybiphenyl + 4 CO2	-	?
additional information	the enzyme also catalyzes the reaction of EC 2.3.1.208, 4-hydroxycoumarin synthase, with malonyl-CoA and 2-hydroxybenzoyl-CoA, i.e. salicoyl-CoA, as substrates forming 4-hydroxycoumarin, no formation of 2',3,5-trihydroxybiphenyl	Sorbus aucuparia	?	-	?

Synonyms

Synonyms	Comment	Organism
BIS	-	Malus sylvestris
BIS	-	Malus domestica
BIS	-	Chaenomeles japonica
BIS	-	Pyrus communis
BIS	-	Rhaphiolepis bibas
BIS	-	Sorbus aucuparia
BIS	-	Photinia glabra
BIS	-	Rhaphiolepis umbellata
BIS	-	Aronia arbutifolia
BIS	-	Chaenomeles cathayensis
BIS	-	Malus sieversii

Expression

Organism	Comment	Expression
Malus sylvestris	the enzyme is induced by elicitors	up
Malus domestica	the enzyme is induced by elicitors	up
Chaenomeles japonica	the enzyme is induced by elicitors	up
Pyrus communis	the enzyme is induced by elicitors	up
Rhaphiolepis bibas	the enzyme is induced by elicitors	up
Sorbus aucuparia	the enzyme is induced by elicitors	up
Photinia glabra	the enzyme is induced by elicitors	up
Rhaphiolepis umbellata	the enzyme is induced by elicitors	up
Aronia arbutifolia	the enzyme is induced by elicitors	up
Chaenomeles cathayensis	the enzyme is induced by elicitors	up
Malus sieversii	the enzyme is induced by elicitors	up

General Information

General Information	Comment	Organism
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Malus sylvestris
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Malus domestica
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Chaenomeles japonica
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Pyrus communis
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Rhaphiolepis bibas
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Sorbus aucuparia
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Photinia glabra
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Rhaphiolepis umbellata
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Aronia arbutifolia
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Chaenomeles cathayensis
evolution	the type-III polyketide synthase biphenyl synthase is encoded by a gene family, members of which are differentially regulated	Malus sieversii
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Malus sylvestris
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Malus domestica
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Chaenomeles japonica
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Pyrus communis
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Rhaphiolepis bibas
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Photinia glabra
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Rhaphiolepis umbellata
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Aronia arbutifolia
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Chaenomeles cathayensis
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin	Malus sieversii
metabolism	biphenyl synthase is the key enzyme that forms the carbon skeleton, it is involved in biosynthesis of aucuparin. Biosynthetic reactions leading to biphenyl and dibenzofuran phytoalexins in cell cultures of Sorbus aucuparia, overview	Sorbus aucuparia
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Malus sylvestris
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Malus domestica
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Chaenomeles japonica
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Pyrus communis
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Rhaphiolepis bibas
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Sorbus aucuparia
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Photinia glabra
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Rhaphiolepis umbellata
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Aronia arbutifolia
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Chaenomeles cathayensis
additional information	biphenyls exhibit stronger antibacterial activity than structurally related dibenzofurans do, occurrence of dibenzofuran phytoalexins in species of the Pyrinae, overview	Malus sieversii
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Malus sylvestris
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Malus domestica
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Chaenomeles japonica
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Pyrus communis
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Rhaphiolepis bibas
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Sorbus aucuparia
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Photinia glabra
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Rhaphiolepis umbellata
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Aronia arbutifolia
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Chaenomeles cathayensis
physiological function	biphenyls, whose biosynthesis involves the biphenyl synthase, and dibenzofurans are the phytoalexins of the Pyrinae, corresponding to the Maloideae, a subfamily of the plant family Rosaceae. Occurrence of biphenyl phytoalexins in species of the Pyrinae, overview	Malus sieversii