Literature summary for 2.3.1.180 extracted from

Alhamadsheh, M.M.; Musayev, F.; Komissarov, A.A.; Sachdeva, S.; Wright, H.T.; Scarsdale, N.; Florova, G.; Reynolds, K.A.
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes (2007), Chem. Biol., 14, 513-524.

Search for more literature for 2.3.1.180

Crystallization (Commentary)

Crystallization (Comment)	Organism
cyrstals of ecFabH and the ecFabH/methyl-CoA disulfide complex are obtained by the hanging drop method	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
decyl-CoA disulfide	-	Mycobacterium tuberculosis
methyl-CoA disulfide	-	Escherichia coli
additional information	no significant inhibitory activity at 0.3 mM: butyl-CoA disulfide, sec-butyl-CoA disulfide, octyl-CoA disulfide, decyl-CoA disulfide	Escherichia coli
additional information	no significant inhibitory activity at 0.3 mM: methyl-CoA disulfide, butyl-CoA disulfide, sec-butyl-CoA disulfide	Mycobacterium tuberculosis
octyl-CoA disulfide	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Mycobacterium tuberculosis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + malonyl-[acyl-carrier protein]	-	Escherichia coli	acetoacetyl-[acyl-carrier protein] + CoA + CO2	-	?
acetyl-CoA + malonyl-[acyl-carrier protein]	-	Mycobacterium tuberculosis	acetoacetyl-[acyl-carrier protein] + CoA + CO2	-	?

Synonyms

Synonyms	Comment	Organism
ecFabH	-	Escherichia coli
FabH	-	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0012	-	-	Mycobacterium tuberculosis	decyl-CoA disulfide
0.0301	-	-	Mycobacterium tuberculosis	octyl-CoA disulfide
0.0571	-	-	Escherichia coli	methyl-CoA disulfide

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)