Literature summary for 2.3.1.180 extracted from

Lee, J.Y.; Jeong, K.W.; Lee, J.U.; Kang, D.I.; Kim, Y.
Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics (2009), Bioorg. Med. Chem., 17, 1506-1513.

Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment)	Organism
gene fabH, expression in Escherichia coli strain BL21(DE3)	Escherichia coli K-12

Inhibitors

Inhibitors	Comment	Organism	Structure
3-[(1E)-N-(4-methyl-1,3-thiazol-2-yl)ethanehydrazonoyl]phenol	i.e. YKA3003	Escherichia coli K-12
3-[2-(3,4-dihydroxyphenyl)-1-methyl-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one	i.e. YKA3001	Escherichia coli K-12
4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol	i.e. YKA3013	Escherichia coli K-12
additional information	inhibitor design, structures, and binding analysis, antibacterial activities, overview	Escherichia coli K-12

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli K-12	-	gene fabH	-

Synonyms

Synonyms	Comment	Organism
beta-ketoacyl-acyl carrier protein synthase III	-	Escherichia coli K-12
KAS III	-	Escherichia coli K-12

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Escherichia coli K-12

General Information

General Information	Comment	Organism
physiological function	KAS III is a condensing enzyme that initiates fatty acid biosynthesis	Escherichia coli K-12

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Release 2023.1 (January 2023)