KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0053 | - |
isovaleryl-CoA | 30°C | Listeria monocytogenes | |
0.0063 | - |
2-methylbutyryl-CoA | 10°C | Listeria monocytogenes | |
0.011 | - |
2-methylbutyryl-CoA | 30°C | Listeria monocytogenes | |
0.0169 | - |
isovaleryl-CoA | 10°C | Listeria monocytogenes | |
0.0243 | - |
isobutyryl-CoA | 30°C | Listeria monocytogenes | |
0.0307 | - |
isobutyryl-CoA | 10°C | Listeria monocytogenes | |
0.0985 | - |
acetyl-CoA | 30°C | Listeria monocytogenes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes | - |
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes 10403S | - |
3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes | - |
acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes 10403S | - |
acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
butyryl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes | - |
3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
isobutyryl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes | - |
3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
isovaleryl-CoA + malonyl-[acyl-carrier protein] | Listeria monocytogenes | - |
3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
additional information | Listeria monocytogenes | beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria | ? | - |
? | |
additional information | Listeria monocytogenes 10403S | beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Listeria monocytogenes | C0LNR0 | gene fabH | - |
Listeria monocytogenes 10403S | C0LNR0 | gene fabH | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes | 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | 2-methylbutyryl-CoA is the preferred substrate | Listeria monocytogenes | 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes 10403S | 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] | 2-methylbutyryl-CoA is the preferred substrate | Listeria monocytogenes 10403S | 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes 10403S | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
butyryl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes | 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
isobutyryl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes | 3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
isovaleryl-CoA + malonyl-[acyl-carrier protein] | - |
Listeria monocytogenes | 3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
additional information | beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria | Listeria monocytogenes | ? | - |
? | |
additional information | substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview | Listeria monocytogenes | ? | - |
? | |
additional information | beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria | Listeria monocytogenes 10403S | ? | - |
? | |
additional information | substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview | Listeria monocytogenes 10403S | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FabH | - |
Listeria monocytogenes |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
10 | 30 | assay at | Listeria monocytogenes |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0007 | - |
acetyl-CoA | 30°C | Listeria monocytogenes | |
0.018 | - |
isovaleryl-CoA | 10°C | Listeria monocytogenes | |
0.102 | - |
isobutyryl-CoA | 10°C | Listeria monocytogenes | |
0.105 | - |
2-methylbutyryl-CoA | 10°C | Listeria monocytogenes | |
0.12 | - |
isovaleryl-CoA | 30°C | Listeria monocytogenes | |
0.32 | - |
isobutyryl-CoA | 30°C | Listeria monocytogenes | |
0.46 | - |
2-methylbutyryl-CoA | 30°C | Listeria monocytogenes |
General Information | Comment | Organism |
---|---|---|
metabolism | beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria | Listeria monocytogenes |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.17 | - |
acetyl-CoA | 30°C | Listeria monocytogenes | |
1.67 | - |
isovaleryl-CoA | 10°C | Listeria monocytogenes | |
3.33 | - |
isobutyryl-CoA | 10°C | Listeria monocytogenes | |
6.67 | - |
2-methylbutyryl-CoA | 10°C | Listeria monocytogenes | |
13.3 | - |
isobutyryl-CoA | 30°C | Listeria monocytogenes | |
23.3 | - |
isovaleryl-CoA | 30°C | Listeria monocytogenes | |
41.7 | - |
2-methylbutyryl-CoA | 30°C | Listeria monocytogenes |