Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Lip3 is unable to modify either lipoyl domains or glycine cleavage system 3 when provided with free octanoate, ATP and MgCl2 | Saccharomyces cerevisiae | ? | - |
? | |
octanoyl-CoA + [glycine cleavage system 3]-L-lysine | - |
Saccharomyces cerevisiae | [glycine cleavage system 3]-N6-octanoyl-L-lysine + CoA | - |
? | |
octanoyl-CoA + [oxoglutarate dehydrogenase]-L-lysine | - |
Saccharomyces cerevisiae | [oxoglutarate dehydrogenase]-N6-octanoyl-L-lysine + CoA | - |
? | |
octanoyl-CoA + [pyruvate dehydrogenase]-L-lysine | - |
Saccharomyces cerevisiae | [pyruvate dehydrogenase]-N6-octanoyl-L-lysine + CoA | - |
? | |
octanoyl-[acyl-carrier protein] + [glycine cleavage system 3]-L-lysine | - |
Saccharomyces cerevisiae | [glycine cleavage system 3]-N6-octanoyl-L-lysine + acyl-carrier protein | in vitro reaction | ? |
Synonyms | Comment | Organism |
---|---|---|
LIP3 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | octanoyltransferase Lip2 specifically modifies glycine cleavage system 3 using octanoyl-ACP from mitochondrial FA biosynthesis. When all glycine cleavage system 3 is octanoylated, octanoyl-ACP accumulates. An octanoyl-ACP: CoA transferase transfers the octanoyl moiety to CoA, providing substrate for octanoyltransferase Lip3 to modify pyruvate dehydrogenase and oxoglutarate dehydrogenase. Complementation of the Escherichia coli DELTAlipB DELTAlplA strain by expression of Lip3 requires a host-encoded acyl-CoA synthase | Saccharomyces cerevisiae |