Application | Comment | Organism |
---|---|---|
drug development | synthetic inhibitors of acyl-HSL synthases might be useful therapeutically for controlling pathogens | Burkholderia glumae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E9C-3oxoC6 | competitively inhibits N-octanoyl -L-homoserine lactone binding to TofR, binding structure, overview | Burkholderia glumae | |
J8-C8 | binds to TofI, occupying the binding site for the acyl chain of the TofI cognate substrate, acylated acyl-carrier protein, and reaction byproduct, 5'-methylthioadenosine, independently binds to the binding site for a second substrate, S-adenosyl-L-methionine, TofI(3MDELTA)/J8-C8/MTA ternary complex, binding structure, overview. In the ternary complex, J8-C8 is bound to the pocket observed in the apo-TofI(3M?) structure. The octanoyl chain is almost in an elongated conformation | Burkholderia glumae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Burkholderia glumae | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone | - |
? | |
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Burkholderia glumae BGR1 | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Burkholderia glumae | - |
gene ahpF | - |
Burkholderia glumae BGR1 | - |
gene ahpF | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Burkholderia glumae | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone | - |
? | |
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Burkholderia glumae BGR1 | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl-HSL synthase | - |
Burkholderia glumae |
N-acyl-homoserine lactone synthase | - |
Burkholderia glumae |
TofI | - |
Burkholderia glumae |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in quorum sensing and biosynthesis of N-acyl-L-homoserine lactones. Quorum sensing controls certain behaviors of bacteria in response to population density and influences the virulence. In Gram-negative bacteria, quorum sensing is often mediated by N-acyl-L-homoserine lactones. Quorum sensing controls virulence, motility, and protein secretion and is mediated by the binding of N-octanoyl-L-homoserine lactone to its cognate receptor, TofR | Burkholderia glumae |