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Literature summary for 2.3.1.184 extracted from

  • Chang, C.; Krishnan, T.; Wang, H.; Chen, Y.; Yin, W.; Chong, Y.; Tan, L.; Chong, T.; Chan, K.
    Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target (2014), Sci. Rep., 4, 7245.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
salicylic acid
-
Pseudomonas aeruginosa
Tannic acid efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI Pseudomonas aeruginosa
trans-cinnamaldehyde efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI. trans-Cinnamaldehyde reduces the quorum-sensing-regulated pyocyanin production up to 42%; molecular docking ananlysis, mainly interacts with substrate binding sites. trans-Cinnamaldehyde is locked deeply into the binding site and forms hydrophobic and Pi-Pi interactions with surrounding residues Phe27, Trp33 and Phe105 and one hydrogen bond with Arg30 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa P33883
-
-
Pseudomonas aeruginosa P54291
-
-

Synonyms

Synonyms Comment Organism
LasI
-
Pseudomonas aeruginosa
RhlI
-
Pseudomonas aeruginosa