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Literature summary for 2.3.1.189 extracted from
- Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes (2002), Arch. Microbiol., 178, 331-337.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| desacetylmycothiol + acetyl-CoA | Mycobacterium tuberculosis | this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes | mycothiol + coenzyme-A | - |
? |  |
| desacetylmycothiol + acetyl-CoA | Mycobacterium tuberculosis H37Rv | this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes | mycothiol + coenzyme-A | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WJM7 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WJM7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| desacetylmycothiol + acetyl-CoA | - |
Mycobacterium tuberculosis | mycothiol + coenzyme-A | - |
? | |
| desacetylmycothiol + acetyl-CoA | this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes | Mycobacterium tuberculosis | mycothiol + coenzyme-A | - |
? | |
| desacetylmycothiol + acetyl-CoA | - |
Mycobacterium tuberculosis H37Rv | mycothiol + coenzyme-A | - |
? | |
| desacetylmycothiol + acetyl-CoA | this enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes | Mycobacterium tuberculosis H37Rv | mycothiol + coenzyme-A | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MshD | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | production of a Mycobacterium smegmatis transposon mutant blocked in the production of mycothill as the result of lacking the transacetylase activity of mycothiol synthase | Mycobacterium tuberculosis |
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