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Literature summary for 2.3.1.194 extracted from

  • Hasegawa, S.; Kume, H.; Iinuma, S.; Yamasaki, M.; Takahashi, N.; Kukui, T.
    Acetoacetyl-CoA synthetase is essential for normal neuronal development (2012), Biochem. Biophys. Res. Commun., 427, 398-403.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
AACS expression analysis during development, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain high enzyme expression level Mus musculus
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embryo expression of AACS in the brains of mouse embryos is dramatically increased between E16.5 and E18.5 Mus musculus
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additional information AACS expression analysis during development, overview Mus musculus
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Neuro-2a cell mRNA levels and the expression of AACS are increased during neurite outgrowth Mus musculus
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Synonyms

Synonyms Comment Organism
AACS
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Mus musculus

Expression

Organism Comment Expression
Mus musculus SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells down

General Information

General Information Comment Organism
malfunction knockdown of AACS in primary neurons caused decreases in the expression of MAP-2 and NeuN, which are markers of neuronal differentiation, as well as synaptopodin, a marker of spine apparatus Mus musculus
additional information SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells Mus musculus
physiological function acetoacetyl-CoA synthetase is a ketone body-utilizing enzyme for the synthesis of cholesterol and fatty acids, regulation of AACS during neurite outgrowth and physiological role of AACS in neurogenesis, overview. AACS is regulated by SREBP-2 and involved in the normal development of neurons Mus musculus