Cloned (Comment) | Organism |
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AACS expression analysis during development, overview | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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brain | high enzyme expression level | Mus musculus | - |
embryo | expression of AACS in the brains of mouse embryos is dramatically increased between E16.5 and E18.5 | Mus musculus | - |
additional information | AACS expression analysis during development, overview | Mus musculus | - |
Neuro-2a cell | mRNA levels and the expression of AACS are increased during neurite outgrowth | Mus musculus | - |
Synonyms | Comment | Organism |
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AACS | - |
Mus musculus |
Organism | Comment | Expression |
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Mus musculus | SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells | down |
General Information | Comment | Organism |
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malfunction | knockdown of AACS in primary neurons caused decreases in the expression of MAP-2 and NeuN, which are markers of neuronal differentiation, as well as synaptopodin, a marker of spine apparatus | Mus musculus |
additional information | SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells | Mus musculus |
physiological function | acetoacetyl-CoA synthetase is a ketone body-utilizing enzyme for the synthesis of cholesterol and fatty acids, regulation of AACS during neurite outgrowth and physiological role of AACS in neurogenesis, overview. AACS is regulated by SREBP-2 and involved in the normal development of neurons | Mus musculus |