Literature summary for 2.3.1.20 extracted from

McFie, P.J.; Banman, S.L.; Kary, S.; Stone, S.J.
Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum (2011), J. Biol. Chem., 286, 28235-28246.

Search for more literature for 2.3.1.20

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293T cell	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	an isoform DGAT2 mutant lacking both its transmembrane domains still associates with membranes, but is absent from the endoplasmic reticulum and instead localizes to mitochondria. The mutant is still active and capable of interacting with lipid droplets to promote triacylglycerol storage. Mutants, in which regions of the C-terminus are either truncated or specific regions are deleted, fail to co-localize with lipid droplets when cells are loaded with oleate to stimulate triacylglycerol synthesis	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	the endoplasmic reticulum targeting signal is present in the first transmembrane domain, TMD1, of isoform DGAT2	Mus musculus	5783	-
lipid droplet	the interaction of isoform DGAT2 with lipid droplets is dependent on the C-terminus. Mutants, in which regions of the C-terminus are either truncated or specific regions are deleted, failed to co-localize with lipid droplets when cells are oleate loaded to stimulate triacylglycerol synthesis	Mus musculus	5811	-
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9DCV3	isoform DGAT2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Subunits

Subunits	Comment	Organism
More	individual isoform DGAT2 subunits are capable of interacting as part of a multimeric complex. Multiple domains, both in the N and C termini, mediate subunit interaction	Mus musculus

Synonyms

Synonyms	Comment	Organism
DGAT2	-	Mus musculus

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Release 2023.1 (January 2023)