Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 malonyl-CoA + hexanoyl-CoA | Cannabis sativa | - |
3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cannabis sativa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | - |
Cannabis sativa | - |
inflorescence | very high levels of cannabinoids in the flower tops | Cannabis sativa | - |
leaf | upper | Cannabis sativa | - |
additional information | no activity in seeds, roots, stems, and lower leaves | Cannabis sativa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 malonyl-CoA + hexanoyl-CoA | - |
Cannabis sativa | 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | formation of olivetol via C12-polyketide, no formation of olivetolic acid, product identification by its UV-spectrum, mass spectrometry analysis and comparison with reference compound | ? | |
3 malonyl-CoA + hexanoyl-CoA | - |
Cannabis sativa | 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | formation of olivetol via C12-polyketide by condensation and cyclization reactions, stilbene synthase like mechanism, overview. No formation of olivetolic acid, UV-spectrum and mass spectrometry analysis | ? |
Synonyms | Comment | Organism |
---|---|---|
PKS | - |
Cannabis sativa |
polyketide synthase | - |
Cannabis sativa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Cannabis sativa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Cannabis sativa |
General Information | Comment | Organism |
---|---|---|
metabolism | the polyketide synthase catalyzes the first step of cannabinoid biosynthesis, leading to olivetolic acid | Cannabis sativa |
physiological function | olivetolic acid is the first intermediate involved in the cannabinoid biosynthesis in Cannabis sativa leading to the acidic forms of the major cannabinoids such as DELTA9-tetrahydrocannabinolic acid and cannabinolic acid | Cannabis sativa |