Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.21 extracted from

  • Bruce, C.R.; Brolin, C.; Turner, N.; Cleasby, M.E.; van der Leij, F.R.; Cooney, G.J.; Kraegen, E.W.
    Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1231-E1237.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CPT 1B, overexpression in isolated extensor digitorum longus, EDL, muscle strips, electrotransfection Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of CPT I in skeletal muscle in vivo increases fatty acid oxidation, i.e. palmitate oxidation by 28%, and reduces triacylglycerol esterification, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA the activity of CPT I is largely controlled by cytosolic levels of its biological inhibitor malonyl-CoA, being a key regulator of fatty acid partitioning in skeletal muscle by virtue of its ability to inhibit CPT I Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane of subsarcolemmal mitochondria, transmembrane enzyme Homo sapiens 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Homo sapiens CPT I is considered the rate-limiting step in the oxidation of long-chain fatty acids and is an important site in the regulation of flux through beta-oxidation CoA + L-palmitoylcarnitine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene CPT IB
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine CPT I is considered the rate-limiting step in the oxidation of long-chain fatty acids and is an important site in the regulation of flux through beta-oxidation Homo sapiens CoA + L-palmitoylcarnitine
-
?
palmitoyl-CoA + L-carnitine the enzyme catalyzes the transfer of an acyl-CoA moiety from a long-chain acyl-CoA ester to carnitine to form acylcarnitine Homo sapiens CoA + L-palmitoylcarnitine
-
?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase I
-
Homo sapiens
CPT I
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
assay at Homo sapiens