Cloned (Comment) | Organism |
---|---|
gene CPT 1B, overexpression in isolated extensor digitorum longus, EDL, muscle strips, electrotransfection | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of CPT I in skeletal muscle in vivo increases fatty acid oxidation, i.e. palmitate oxidation by 28%, and reduces triacylglycerol esterification, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
malonyl-CoA | the activity of CPT I is largely controlled by cytosolic levels of its biological inhibitor malonyl-CoA, being a key regulator of fatty acid partitioning in skeletal muscle by virtue of its ability to inhibit CPT I | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial outer membrane | of subsarcolemmal mitochondria, transmembrane enzyme | Homo sapiens | 5741 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-carnitine | Homo sapiens | CPT I is considered the rate-limiting step in the oxidation of long-chain fatty acids and is an important site in the regulation of flux through beta-oxidation | CoA + L-palmitoylcarnitine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene CPT IB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-carnitine | CPT I is considered the rate-limiting step in the oxidation of long-chain fatty acids and is an important site in the regulation of flux through beta-oxidation | Homo sapiens | CoA + L-palmitoylcarnitine | - |
? | |
palmitoyl-CoA + L-carnitine | the enzyme catalyzes the transfer of an acyl-CoA moiety from a long-chain acyl-CoA ester to carnitine to form acylcarnitine | Homo sapiens | CoA + L-palmitoylcarnitine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase I | - |
Homo sapiens |
CPT I | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.1 | - |
assay at | Homo sapiens |