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Literature summary for 2.3.1.21 extracted from

  • Ratheiser, K.; Schneeweiss, B.; Waldhaeusl, W.; Fasching, P.; Korn, A
    Nowotny, P.; Rohac, M.; Wolf, H.P.O.: Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus (1991), Metabolism, 40, 1185-1190.
    View publication on PubMed
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
etomoxir etomoxir is a racemate of two optically active phenoxyalkyloxirane carboxylic acid ethyl esters, of which only the (+), but not the (-)-enantiomer, inhibits CPT-I Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Homo sapiens enzyme inhibition reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus, overview CoA + L-palmitoylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 obese NIDDM patients
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine enzyme inhibition reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus, overview Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase I
-
 Homo sapiens
CPT I
-
 Homo sapiens