Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.22 extracted from

  • Orland, M.D.; Anwar, K.; Cromley, D.; Chu, C.; Chen, L.; Billheimer, J.T.; Hussain, M.M.; Cheng, D.
    Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1 (2005), Biochim. Biophys. Acta, 1737, 76-82.
    View publication on PubMed
Search for more literature for 2.3.1.22

Inhibitors

Inhibitors Comment Organism Structure
XP620 selective isozyme DGAT1 inhibitor, inhibits the diacylglycerol acyltransferase and the retinol acyltransferase activities at the retinol recognition site Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1,2-diacylglycerol Homo sapiens
-
 CoA + triacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme DGAT1
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1,2-diacylglycerol
-
 Homo sapiens CoA + triacylglycerol
-
 ?
additional information isozyme DGAT1 also performs the reaction of the retinol O-fatty-acyltransferase, EC 2.3.1.76 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
acyl coenzyme A:diacylglycerol acyltransferase
-
 Homo sapiens
DGAT
-
 Homo sapiens
DGAT1/ARAT
-
 Homo sapiens
More cf. EC 2.3.1.76 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics depend highly on retinol concentration, overview, recombinant enzyme Homo sapiens