Literature summary for 2.3.1.238 extracted from

Kennedy, J.; Auclair, K.; Kendrew, S.G.; Park, C.; Vederas, J.C.; Hutchinson, C.R.
Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis (1999), Science, 284, 1368-1372.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
46000	-	x * 46000, SDS-PAGE	Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]	Aspergillus terreus	-	lovastatin acid + [2-methylbutanoate polyketide synthase]	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus terreus	Q9Y7D1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]	-	Aspergillus terreus	lovastatin acid + [2-methylbutanoate polyketide synthase]	-	?
monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase]	monacolin J acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate	Aspergillus terreus	lovastatin acid + [2-methylbutanoate polyketide synthase]	lovastatin acid i.e. (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-[[(2S)-2-methylbutanoyl]oxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate	?

Subunits

Subunits	Comment	Organism
?	x * 46000, SDS-PAGE	Aspergillus terreus

Synonyms

Synonyms	Comment	Organism
LovD	-	Aspergillus terreus

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Release 2023.1 (January 2023)