Literature summary for 2.3.1.239 extracted from

Tang, L.; Fu, H.; Betlach, M.C.; McDaniel, R.
Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase (1999), Chem. Biol., 6, 553-558.

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Cloned(Commentary)

Cloned (Comment)	Organism
the picromycin/methymycin PKS genes (pikAI, PikAII, PikAIII, PikAIV and pikAV) are functionally expressed in the heterologous host Streptomyces lividans, resulting in production of both narbonolide and 10-deoxymethynolide	Streptomyces venezuelae

Organism

Organism	UniProt	Comment	Textmining
Streptomyces venezuelae	Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1	Q9ZGI5: type I polyketide synthase PikAI, Q9ZGI4: type I polyketide synthase PikAII, Q9ZGI3: type I polyketide synthase PikAIII, Q9ZGI2: type I polyketide synthase PikAIV, Q9ZGI1: thioesterase II PikAV. Multifunctional, modular enzyme	-

Synonyms

Synonyms	Comment	Organism
picromycin/methymycin PKS	-	Streptomyces venezuelae
picromycin/methymycin polyketide synthase	-	Streptomyces venezuelae

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Release 2023.1 (January 2023)