Literature summary for 2.3.1.239 extracted from

Yin, Y.; Lu, H.; Khosla, C.; Cane, D.E.
Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase (2003), J. Am. Chem. Soc., 125, 5671-5676.

Search for more literature for 2.3.1.239

Cloned(Commentary)

Cloned (Comment)	Organism
expression of functional polyketide synthase modules in Escherichia coli	Streptomyces venezuelae

Organism

Organism	UniProt	Comment	Textmining
Streptomyces venezuelae	Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1	Q9ZGI5: type I polyketide synthase PikAI, Q9ZGI4: type I polyketide synthase PikAII, Q9ZGI3: type I polyketide synthase PikAIII, Q9ZGI2: type I polyketide synthase PikAIV, Q9ZGI1: thioesterase II PikAV. Multifunctional, modular enzyme	-
Streptomyces venezuelae ATCC 15439	Q9ZGI5 and Q9ZGI4 and Q9ZGI3 and Q9ZGI2 and Q9ZGI1	Q9ZGI5: type I polyketide synthase PikAI, Q9ZGI4: type I polyketide synthase PikAII, Q9ZGI3: type I polyketide synthase PikAIII, Q9ZGI2: type I polyketide synthase PikAIV, Q9ZGI1: thioesterase II PikAV. Multifunctional, modular enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	despite clear similarities in biochemistry and underlying module organization the picromycin synthase modules 5+TE(thioesterase) and 6+TE(thioesterase) show clear differences in substrate specificity and tolerance	Streptomyces venezuelae	?	-	?
additional information	despite clear similarities in biochemistry and underlying module organization the picromycin synthase modules 5+TE(thioesterase) and 6+TE(thioesterase) show clear differences in substrate specificity and tolerance	Streptomyces venezuelae ATCC 15439	?	-	?

Subunits

Subunits	Comment	Organism
More	the enzyme is a multifunctional, modular polyketide synthase	Streptomyces venezuelae

Synonyms

Synonyms	Comment	Organism
picromycin/methymycin polyketide synthase	-	Streptomyces venezuelae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
30	-	assay at	Streptomyces venezuelae

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Release 2023.1 (January 2023)