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Literature summary for 2.3.1.26 extracted from

  • Sgoutas, D.S.
    Effect of geometry and position of ethylenic bond upon acyl coenzyme A: cholesterol-O-acyltransferase (1970), Biochemistry, 9, 1826-1833.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0022
-
elaidoyl-CoA
-
Rattus norvegicus
0.0028
-
linoleoyl-CoA
-
Rattus norvegicus
0.004
-
oleoyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for the acylation of free cholesterol Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol acyl-CoA derivatives can be replaced by ATP, Mg2+, CoA and fatty acids, in-situ production of acyl-CoA Rattus norvegicus CoA + cholesterol ester
-
?
acyl-CoA + cholesterol the animal enzyme is highly specific for transfer of acyl groups with a single cis-double-bond 9 carbon atoms distant from the carboxyl group Rattus norvegicus CoA + cholesterol ester
-
?
elaidoyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesteryl elaidate
-
?
linelaidoyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesteryl linelaidate
-
?
linoleoyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesteryl linoleate
-
?
oleoyl-CoA + cholesterol highest activity Rattus norvegicus CoA + cholesteryl oleate
-
?
palmitoyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesteryl palmitate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
CoA required by the in-situ acyl-CoA production Rattus norvegicus