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Literature summary for 2.3.1.26 extracted from

  • Tabas, I.; Chen, L.L.; Clader, J.W.; McPhail, A.T.; Burnett, D.A.; Bartner, P.; Das, P.R.; Pramanik, B.N.; Puar, M.S.; Feinmark, S.J.; Zipkin, R.E.; Boykow, G.; Vita, G.; Tall, A.R.
    Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA:cholesterol acyltransferase inhibitory activity (1990), J. Biol. Chem., 265, 8042-8051.
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
Inhibitor from rabbit liver fatty acid ester, mostly stearate, of a pentacyclic triterpene acid, irreversible inhibition, which is prevented by incubation with bovine serum albumin, half-maximal inhibition occurs at an inhibitor concentration of 0.02 mM Rattus norvegicus
progesterone
-
 Oryctolagus cuniculus
progesterone half-maximal inhibitory concentration of 0.05 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
long-chain fatty acyl-CoA + cholesterol Rattus norvegicus responsible for cellular synthesis of cholesterol esters in various cell types CoA + cholesteryl long-chain fatty acyl ester
-
 ?
long-chain fatty acyl-CoA + cholesterol Oryctolagus cuniculus responsible for cellular synthesis of cholesterol esters in various cell types CoA + cholesteryl long-chain fatty acyl ester
-
 ?
long-chain fatty acyl-CoA + cholesterol Rattus norvegicus role in lipoprotein metabolism and atherogenesis CoA + cholesteryl long-chain fatty acyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol
-
 Oryctolagus cuniculus CoA + cholesterol ester
-
 ?
long-chain fatty acyl-CoA + cholesterol responsible for cellular synthesis of cholesterol esters in various cell types Rattus norvegicus CoA + cholesteryl long-chain fatty acyl ester
-
 ?
long-chain fatty acyl-CoA + cholesterol responsible for cellular synthesis of cholesterol esters in various cell types Oryctolagus cuniculus CoA + cholesteryl long-chain fatty acyl ester
-
 ?
long-chain fatty acyl-CoA + cholesterol role in lipoprotein metabolism and atherogenesis Rattus norvegicus CoA + cholesteryl long-chain fatty acyl ester
-
 ?