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Literature summary for 2.3.1.26 extracted from
- Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice (1995), J. Biol. Chem., 270, 26192-26201.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| low density lipoprotein | - |
Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in enzyme-deficient mutant chinese hamster ovary cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| microsome | - |
Mus musculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 64000 | - |
deduced from amino acid sequence data | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q61263 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | two potential N-glycosylation sites close to the C-terminal end of the polypeptide identified | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | low expression | Mus musculus | - |
| adrenal gland | highly expressed | Mus musculus | - |
| aorta | - |
Mus musculus | - |
| brain | low expression | Mus musculus | - |
| heart | low expression | Mus musculus | - |
| intestine | - |
Mus musculus | - |
| liver | enzyme levels are doubled in animals fed an atherogenic diet | Mus musculus | - |
| additional information | effect of an atherogenic diet upon hepatic and intestinal enzyme mRNA expression and on enzyme mRNA expression in aorta and peritoneal macrophages. Enzyme activity in the liver is regulated at least in part by enzyme mRNA abundance | Mus musculus | - |
| peritoneal macrophage | highly expressed | Mus musculus | - |
| preputial gland | highly expressed | Mus musculus | - |
| skeletal muscle | low expression | Mus musculus | - |
| testis | - |
Mus musculus | - |
| thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oleoyl-CoA + cholesterol | - |
Mus musculus | CoA + cholesteryl oleate | - |
? |  |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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