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Literature summary for 2.3.1.26 extracted from

  • Gelain, A.; Barlocco, D.; Kwon, B.M.; Jeong, T.S.; Im, K.R.; Legnani, L.; Toma, L.
    3-Heptylamino-5-phenylpyridazine derivatives as analogues of acyl-CoA: cholesterol acyltransferase inhibitors containing the N-heptyl-N-arylureidic moiety (2006), Arch. Pharm., 339, 645-651.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3,6-dimethylpyrazin-2-yl)-4-(5-phenylpyridazin-3-yl)-1,4-diazepane 0.1 mg/ml, 62% inhibition Rattus norvegicus
3-[4-(3,6-dimethylpyrazin-2-yl)piperazin-1-yl]-5-phenylpyridazine 0.1 mg/ml, 57% inhibition Rattus norvegicus
GERI-BP001M 0.1 mg/ml, 82% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N,N-diheptylbutane-1,4-diamine 0.1 mg/ml, 55% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N,N-diheptylpentane-1,5-diamine 0.1 mg/ml, 58% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N,N-diheptylpropane-1,3-diamine 0.1 mg/ml, 52% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)butane-1,4-diamine 0.1 mg/ml, 87% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)heptane-1,7-diamine 0.1 mg/ml, 58% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 79% inhibition; 0.1 mg/ml, 95% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)octane-1,8-diamine 0.1 mg/ml, 76% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)pentane-1,5-diamine 0.1 mg/ml, 79% inhibition Rattus norvegicus
N'-(3,6-dimethylpyrazin-2-yl)-N-heptyl-N-(5-phenylpyridazin-3-yl)propane-1,3-diamine 0.1 mg/ml, 70% inhibition Rattus norvegicus
N-(3,6-dimethylpyrazin-2-yl)-N'-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 89% inhibition Rattus norvegicus
N-(5,6-diphenylpyridazin-3-yl)-N'-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 88% inhibition Rattus norvegicus
N-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 72% inhibition Rattus norvegicus
N-(6-chloropyridazin-3-yl)-N'-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 83% inhibition Rattus norvegicus
N-(6-methoxypyridazin-3-yl)-N'-(5-phenylpyridazin-3-yl)hexane-1,6-diamine 0.1 mg/ml, 83% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oleoyl-CoA + cholesterol
-
Rattus norvegicus CoA + cholesterol oleate
-
?

Synonyms

Synonyms Comment Organism
ACAT
-
Rattus norvegicus
acyl-CoA: cholesterol acyltransferase
-
Rattus norvegicus