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Literature summary for 2.3.1.26 extracted from

  • Fujiwara, Y.; Kiyota, N.; Hori, M.; Matsushita, S.; Iijima, Y.; Aoki, K.; Shibata, D.; Takeya, M.; Ikeda, T.; Nohara, T.; Nagai, R.
    Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT (2007), Arterioscler. Thromb. Vasc. Biol., 27, 2400-2406.
    View publication on PubMed

Application

Application Comment Organism
medicine the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis Mus musculus
medicine the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CI976
-
Homo sapiens
CI976
-
Mus musculus
esculeogenin A
-
Homo sapiens
esculeogenin A
-
Mus musculus
esculeoside A
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
rough endoplasmic reticulum
-
Mus musculus 5791
-
rough endoplasmic reticulum
-
Homo sapiens 5791
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Mus musculus
-
CoA + cholesterol ester
-
?
acyl-CoA + cholesterol Homo sapiens
-
CoA + cholesterol ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomes prepared from monocyte-derived macrophagesare are used as an enzyme source Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Mus musculus
-
liver
-
Mus musculus
-
macrophage monocyte-derived macrophage Homo sapiens
-
peritoneal macrophage
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000081
-
ACAT activity in liver, 100 mg/kg/day esculeoside A Mus musculus
0.000088
-
ACAT activity in peritoneal macrophage, 100 mg/kg/day esculeoside A Mus musculus
0.000144
-
ACAT activity in intestine, 100 mg/kg/day esculeoside A Mus musculus
0.000144
-
ACAT activity in intestine, control Mus musculus
0.00015
-
ACAT activity in peritoneal macrophage, control Mus musculus
0.000156
-
ACAT activity in liver, control Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
Mus musculus CoA + cholesterol ester
-
?
acyl-CoA + cholesterol
-
Homo sapiens CoA + cholesterol ester
-
?

Synonyms

Synonyms Comment Organism
ACAT
-
Mus musculus
ACAT
-
Homo sapiens
acyl-coenzymeA:cholesterol acyl-transferase
-
Mus musculus
acyl-coenzymeA:cholesterol acyl-transferase
-
Homo sapiens
hACAT
-
Homo sapiens