Application | Comment | Organism |
---|---|---|
medicine | the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis | Mus musculus |
medicine | the study provides evidence that purified esculeogenin A significantly suppresses the activity of ACAT protein and leads to reduction of atherogenesis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CI976 | - |
Homo sapiens | |
CI976 | - |
Mus musculus | |
esculeogenin A | - |
Homo sapiens | |
esculeogenin A | - |
Mus musculus | |
esculeoside A | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
rough endoplasmic reticulum | - |
Mus musculus | 5791 | - |
rough endoplasmic reticulum | - |
Homo sapiens | 5791 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | Mus musculus | - |
CoA + cholesterol ester | - |
? | |
acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
microsomes prepared from monocyte-derived macrophagesare are used as an enzyme source | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
macrophage | monocyte-derived macrophage | Homo sapiens | - |
peritoneal macrophage | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000081 | - |
ACAT activity in liver, 100 mg/kg/day esculeoside A | Mus musculus |
0.000088 | - |
ACAT activity in peritoneal macrophage, 100 mg/kg/day esculeoside A | Mus musculus |
0.000144 | - |
ACAT activity in intestine, 100 mg/kg/day esculeoside A | Mus musculus |
0.000144 | - |
ACAT activity in intestine, control | Mus musculus |
0.00015 | - |
ACAT activity in peritoneal macrophage, control | Mus musculus |
0.000156 | - |
ACAT activity in liver, control | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | - |
Mus musculus | CoA + cholesterol ester | - |
? | |
acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACAT | - |
Mus musculus |
ACAT | - |
Homo sapiens |
acyl-coenzymeA:cholesterol acyl-transferase | - |
Mus musculus |
acyl-coenzymeA:cholesterol acyl-transferase | - |
Homo sapiens |
hACAT | - |
Homo sapiens |