Literature summary for 2.3.1.26 extracted from

Vojtassakova, E.; Synekova, M.; Tazka, D.; Matyas, S.; Hozova, R.; Sadlonova, I.; Svec, P.
Effect of VULM 1457, an ACAT inhibitor, on serum lipid levels and on real time red blood cell flow in diabetic and non-diabetic hamsters fed high cholesterol-lipid diet (2007), Gen. Physiol. Biophys., 26, 254-259.

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Application

Application	Comment	Organism
medicine	the results suggest that the ACAT inhibitor VULM 1457 is a prospective hypolipidemic and anti-atherogenic drug which treats diabetes	Mesocricetus auratus

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(2,6-diisopropyl-phenyl)-3-[4-(4'-nitrophenylthio)phenyl] urea	VULM 1457	Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acyl-CoA + cholesterol	Mesocricetus auratus	-	CoA + cholesterol ester	-	?

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	Syrian hamster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acyl-CoA + cholesterol	-	Mesocricetus auratus	CoA + cholesterol ester	-	?

Synonyms

Synonyms	Comment	Organism
ACAT	two ACAT genes have been identified in mammals, ACAT-1 and ACAT-2	Mesocricetus auratus
acyl-coenzyme A:cholesterol O-acyltransferase	-	Mesocricetus auratus

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Release 2023.1 (January 2023)