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Literature summary for 2.3.1.26 extracted from

  • Choi, J.H.; Rho, M.; Lee, S.W.; Kwon, O.E.; Park, H.R.; Kang, J.Y.; Lee, S.H.; Lee, H.S.; Bae, K.H.; Kim, Y.K.
    Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots (2007), J. Ethnopharmacol., 110, 563-566.
    View publication on PubMed
Search for more literature for 2.3.1.26

Application

Application Comment Organism
pharmacology the data suggest that antiatherosclerotic activity of licorice in hypercholesterolemic patients might be related with its ACAT inhibitory effects Homo sapiens
pharmacology the data suggest that antiatherosclerotic activity of licorice in hypercholesterolemic patients might be related with its ACAT inhibitory effects Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
glabrol
-
 Homo sapiens
glabrol
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol Rattus norvegicus
-
 CoA + cholesterol ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol activity assay Homo sapiens ?
-
 ?
oleoyl-CoA + cholesterol activity assay Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACAT
-
 Homo sapiens
ACAT
-
 Rattus norvegicus
acyl-coenzyme A: cholesterol acyltransferase
-
 Homo sapiens
acyl-coenzyme A: cholesterol acyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Homo sapiens
37
-
 activity assay Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0246
-
-
 Rattus norvegicus glabrol
0.026
-
-
 Homo sapiens glabrol