Application | Comment | Organism |
---|---|---|
medicine | an anti-oxidative ACAT inhibitor or the combination of an antioxidant and an ACAT inhibitor protects foam cells from oxidative stress and effectively reduces cholesterol levels, which would be a promising approach in anti-atherosclerotic therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(4,6-dimethyl-1-pentylindolin-7-yl)-2,2-dimethylpropanamide | KY-455, an anti-oxidative ACAT inhibitor | Homo sapiens | |
YM-750 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
THP-1 cell | THP-1 cell-derived foam cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACAT | - |
Homo sapiens |
acyl-CoA:cholesterol acyltransferase | - |
Homo sapiens |