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Literature summary for 2.3.1.26 extracted from
- ACAT inhibition of alkamides identified in the fruits of Piper nigrum (2007), Phytochemistry, 68, 899-903.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dehydropipernonaline | - |
Homo sapiens |  |
| dehydropipernonaline | - |
Rattus norvegicus | |
| dehydroretrofractamide | - |
Homo sapiens | |
| dehydroretrofractamide | - |
Rattus norvegicus | |
| pellitorin | - |
Homo sapiens | |
| pellitorin | - |
Rattus norvegicus | |
| piperchabamide D | - |
Homo sapiens | |
| piperchabamide D | - |
Rattus norvegicus | |
| pipercide | - |
Homo sapiens | |
| pipercide | - |
Rattus norvegicus | |
| retrofractamide A | - |
Homo sapiens | |
| retrofractamide A | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? | |
| acyl-CoA + cholesterol | Rattus norvegicus | - |
CoA + cholesterol ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver microsomes are prepared | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? | |
| acyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesterol ester | - |
? | |
| oleoyl-CoA + cholesterol | activity assay | Homo sapiens | ? | - |
? | |
| oleoyl-CoA + cholesterol | activity assay | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACAT | - |
Homo sapiens |
| ACAT | - |
Rattus norvegicus |
| acyl-CoA: cholesterol acyltransferase | - |
Homo sapiens |
| acyl-CoA: cholesterol acyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
activity assay | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
activity assay | Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0037 | - |
- |
Rattus norvegicus | pipercide | |
| 0.0135 | - |
- |
Rattus norvegicus | piperchabamide D | |
| 0.0245 | - |
- |
Rattus norvegicus | retrofractamide A | |
| 0.0405 | - |
- |
Rattus norvegicus | pellitorin | |
| 0.06 | - |
- |
Rattus norvegicus | dehydroretrofractamide | |
| 0.09 | - |
- |
Rattus norvegicus | dehydropipernonaline | |
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