Literature summary for 2.3.1.26 extracted from

Ayyagari, V.N.; Wang, X.; Diaz-Sylvester, P.L.; Groesch, K.; Brard, L.
Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression - An in vitro study (2020), PLoS ONE, 15, e0228024 .

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Application

Application	Comment	Organism
medicine	a panel of ovarian cancer cell lines (OC-314, SKOV-3 and IGROV-1) displays significant increase in the expression of ACAT1 and cholesterol ester levels compared to primary ovarian epithelial cells. ACAT1 knockdown ovarian cancer cell lines show significant suppression of cell proliferation, migration and invasion compared to their respective controls. ACAT-1 inhibition enhances apoptosis with a concurrent increase in caspases 3/7 activity and decreased mitochondrial membrane potential, and ACAT1-inhibited ovarian cancer cell lines display enhanced chemosensitivity to cisplatin treatment	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P35610	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
IGROV-1 cell	-	Homo sapiens	-
OC-314 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)