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Literature summary for 2.3.1.37 extracted from
- Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306 (2004), FEMS Microbiol. Lett., 236, 175-181.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rhodopseudomonas palustris |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 1 mM, strong | Rhodopseudomonas palustris |  |
| Cu2+ | 1 mM, complete inhibition | Rhodopseudomonas palustris | |
| Fe2+ | 1 mM, strong | Rhodopseudomonas palustris | |
| K+ | slight inhibition | Rhodopseudomonas palustris | |
| Mg2+ | slight inhibition | Rhodopseudomonas palustris | |
| Pb2+ | 1 mM, strong | Rhodopseudomonas palustris | |
| Zn2+ | 1 mM, complete inhibition | Rhodopseudomonas palustris | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.01 | - |
glycine | pH 7.5 | Rhodopseudomonas palustris | |
| 49.55 | - |
succinyl-CoA | pH 7.5 | Rhodopseudomonas palustris | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rhodopseudomonas palustris | Q6RVB3 | - |
- |
| Rhodopseudomonas palustris KUGB306 | Q6RVB3 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 | mechanism, aldimine linkage between pyridoxal 5-phosphate and enzyme | Rhodopseudomonas palustris |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 27.73 | - |
pH 7.5 | Rhodopseudomonas palustris |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + glycine | - |
Rhodopseudomonas palustris | 5-aminolevulinate + CoA + CO2 | - |
? | |
| succinyl-CoA + glycine | - |
Rhodopseudomonas palustris KUGB306 | 5-aminolevulinate + CoA + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | 40 | - |
Rhodopseudomonas palustris |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
retains about 80% of activity | Rhodopseudomonas palustris |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Rhodopseudomonas palustris |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
retains about 80% of activity | Rhodopseudomonas palustris |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rhodopseudomonas palustris | |
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