Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Drosophila melanogaster | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
larva | - |
Drosophila melanogaster | - |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
ALAS | - |
Drosophila melanogaster |
sigma-aminolevulinate synthase | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | mutation in Alas gena cause massive water loss. The cuticle of alas mutant larvae detaches from the epidermis and its basal region is frayed. Reduction of Alas function results in weakening of the extracellular dityrosines network in the cuticle. Alas activity, which initiates heme biosynthesis in the mitochondrion, might be needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure protecting both the cuticle from transcellular infiltration of body fluid and the animal from dehydration | Drosophila melanogaster |