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Literature summary for 2.3.1.37 extracted from

  • Shaik, K.S.; Meyer, F.; Vazquez, A.V.; Floetenmeyer, M.; Cerdan, M.E.; Moussian, B.
    Sigma-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva (2012), Eur. J. Cell Biol., 91, 204-215.
    View publication on PubMed
Search for more literature for 2.3.1.37

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Drosophila melanogaster 5739
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
 Drosophila melanogaster
-

Subunits

Subunits Comment Organism
homodimer
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
ALAS
-
 Drosophila melanogaster
sigma-aminolevulinate synthase
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction mutation in Alas gena cause massive water loss. The cuticle of alas mutant larvae detaches from the epidermis and its basal region is frayed. Reduction of Alas function results in weakening of the extracellular dityrosines network in the cuticle. Alas activity, which initiates heme biosynthesis in the mitochondrion, might be needed for the formation of a dityrosine-based barrier that confers resistance to the internal hydrostatic pressure protecting both the cuticle from transcellular infiltration of body fluid and the animal from dehydration Drosophila melanogaster