Cloned (Comment) | Organism |
---|---|
expressed in eukaryotic cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
M567I | mutant shows 25% of wild-type activity, while its half-life is longer than that of wild-type | Homo sapiens |
additional information | the deletion of 33 amino acids at C-terminal end results in higher catalytic activity both in vitro and in vivo with the longer half-life compared to wild-type | Homo sapiens |
S568G | mutant shows decreased catalytic activity in vitro (20% compared to wild-type), but a higher half-life compared to those of wild-type ALAS2 | Homo sapiens |
V562A | mutant shows a higher catalytic activity in vitro, but a shorter half-life in vivo compared to those of wild-type ALAS2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Homo sapiens | 5-aminolevulinate + CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5-aminolevulinate synthase | - |
Homo sapiens |
ALAS2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |