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Literature summary for 2.3.1.4 extracted from

  • Sacoman, J.; Hollingsworth, R.
    Synthesis and evaluation of an N-acetylglucosamine biosynthesis inhibitor (2011), Carbohydr. Res., 346, 2294-2299.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-acetamido-2,6-dideoxy-6-sulfo-D-glucose analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 2.88 mg/ml Bacillus subtilis
2-acetamido-2,6-dideoxy-6-sulfo-D-glucose analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 4 mg/ml Escherichia coli

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Escherichia coli
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