Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-acetamido-2,6-dideoxy-6-sulfo-D-glucose | analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 2.88 mg/ml | Bacillus subtilis | |
2-acetamido-2,6-dideoxy-6-sulfo-D-glucose | analog of glucosamine-6-phosphate, inhibits acetylation of glucosamine-6-phosphate competitively and by acting as a surrogate substrate. Inhibition of glucosamine production or suitably activated glucosamine in bacteria leads to disruption of the peptidoglycan structure, which results in softening, bulging, deformation, fragility and lysis of the cells. 50% inhibition of bacterial growth at 4 mg/ml | Escherichia coli |
Organism | UniProt | Comment | Textmining |
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Bacillus subtilis | - |
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Escherichia coli | - |
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