Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | kinetic analysis of radioiodinated ApoA-I associated with HDL and radioiodinated ApoB on LDL, mechanism for the effect of LCAT on lipid and lipoprotein changes, overview | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | LCAT is a potential drug target for reducing atherosclerosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of LCAT in male nonhuman primate squirrel monkeys, Saimiri sciureus, using an adenoviral vector affects the lipoprotein metabolism, leading to an antiatherogenic lipoprotein profile by increasing HDL cholesterol and lowering ApoB, overview. Increased LCAT activity is also associated with a change in the size of HDL | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted from liver to blood plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | Homo sapiens | LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol | cholesteryl ester + lysophosphatidylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
liver | expression of LCAT | Homo sapiens | - |
additional information | most LCAT activity is found on high-density lipoprotein, HDL, but approximately 30% is also localized on apolipoprotein B-containing lipoproteins | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? | |
phosphatidylcholine + cholesterol | LCAT is a plasma enzyme produced by the liver, that catalyzes the conversion of cholesterol to cholesteryl esters on lipoproteins by the transacylation of fatty acid from the sn-2 position of phosphatidylcholine to the 3-hydroxyl group on the A-ring of cholesterol | Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Homo sapiens |
lecithin-cholesterol acyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | LCAT is a key enzyme in high-density lipoprotein, HDL, metabolism | Homo sapiens |