Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted from liver to blood plasma | Bubalus bubalis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | Bubalus bubalis | LCAT is a serum enzyme that catalyses esterification of free cholesterol to produce cholesteryl ester. Cholesterol for this reaction comes from peripheral tissues and the donor of the acyl group is lecithin from the high density lipoprotein, HDL, particles | cholesteryl ester + lysophosphatidylcholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bubalus bubalis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Bubalus bubalis | - |
liver | enzyme expression | Bubalus bubalis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
enzyme activity in plasma from healthy buffaloes, and from buffaloes suffering ketosis or haemoglobinuria, overview | Bubalus bubalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + cholesterol | - |
Bubalus bubalis | cholesteryl ester + lysophosphatidylcholine | - |
? | |
phosphatidylcholine + cholesterol | LCAT is a serum enzyme that catalyses esterification of free cholesterol to produce cholesteryl ester. Cholesterol for this reaction comes from peripheral tissues and the donor of the acyl group is lecithin from the high density lipoprotein, HDL, particles | Bubalus bubalis | cholesteryl ester + lysophosphatidylcholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LCAT | - |
Bubalus bubalis |
lecithin cholesterol acyltransferase | - |
Bubalus bubalis |
General Information | Comment | Organism |
---|---|---|
malfunction | LCAT is synthesized in the liver and its synthesis and/or excretion is impaired in hepatocellular diseases as indicated by decreased activity of LCAT, e.g. parturient-haemoglobinuria and ketosis, detection of ketonuria, induced phenotypes, overview | Bubalus bubalis |
physiological function | LCAT is necessary for reverse cholesterol transport from peripheral tissues | Bubalus bubalis |