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Literature summary for 2.3.1.43 extracted from

  • Karavia, E.; Papachristou, D.; Kotsikogianni, I.; Triantafyllidou, I.; Kypreos, K.
    Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice (2013), J. Nutr. Biochem., 24, 567-577.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
LCAT
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Mus musculus
lecithin/cholesterol acyltransferase
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Mus musculus

General Information

General Information Comment Organism
malfunction deficiency in LCAT sensitizes mice to diet-induced hepatic deposition of triglycerides and alterations in hepatic histology and architecture. Mechanistic analysis indicate that this is due to enhanced intestinal absorption of dietary triglycerides, accelerated clearance of postprandial triglycerides from the circulation and reduced rate of hepatic triglyceride secretion. Ectopic expression of human LCAT by gene transfer in LCAT-/- mice fed a Western-type diet for 12 weeks result in a significant reduction in their hepatic triglyceride content and a great improvement of hepatic histology and architecture Mus musculus