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Literature summary for 2.3.1.43 extracted from
- Lecithin-cholesterol acyltransferase in brain: does oxidative stress influence the 24-hydroxycholesterol esterification? (2016), Neurosci. Res., 105, 19-27.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apolipoprotein E | - |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Homo sapiens |  |
| H2O2 | - |
Homo sapiens | |
| additional information | oxidative stress reduced LCAT activity in vitro | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | 24-hydroxycholesterol effectively stimulates the enzyme secretion from astrocytoma cells in culture | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + a sterol | Homo sapiens | - |
1-acylglycerophosphocholine + a sterol ester | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04180 | gene lcat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| glioblastoma cell | - |
Homo sapiens | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
| U-87MG cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + 24-hydroxycholesterol | - |
Homo sapiens | 1-acylglycerophosphocholine + a 24-hydroxycholesterol 3-O-acyl ester | - |
? | |
| phosphatidylcholine + a sterol | - |
Homo sapiens | 1-acylglycerophosphocholine + a sterol ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LCAT | - |
Homo sapiens |
| lecithin-cholesterol acyltransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Homo sapiens | isolectric focusing of 9 isozymes, the intensity of spot e (pI 4.86) is 3fold higher in amyotrophic lateral sclerosis compared to control | 5.26 | 4.51 |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the level of 24-hydroxycholesterol esters is lower in cerebrospinal fluid of patients with amyotrophic lateral sclerosis compared to healthy subjects. Oxidative stress reduced LCAT activity in vitro | Homo sapiens |
| physiological function | since unesterified 24OH-C is neurotoxic in cell culture, the LCATactivity might be addressed to reduce the amount of this oxysterolfor neuron survival. Enhanced enzyme LCAT secretion from astrocytes might represent anadaptive response to the increase of non-esterified 24-hydroxycholesterol percentage, aimed to avoid the accumulation of this neurotoxic compound. The low degree of 24-hydroxycholesterol esterification in cerebrospinal fluid or plasma might reflect reduced activity of enzyme LCAT during neurodegeneration | Homo sapiens |
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Release 2023.1 (January 2023)
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