Activating Compound | Comment | Organism | Structure |
---|---|---|---|
biotin | stimulates | Kocuria rosea | |
biotin | stimulates | Pseudomonas fluorescens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
biotin | - |
Bacillus subtilis | |
biotin | - |
Lysinibacillus sphaericus | |
D-alanine | - |
Lysinibacillus sphaericus | |
D-alanine | - |
Pseudomonas fluorescens | |
D-histidine | - |
Lysinibacillus sphaericus | |
D/L-histidine | - |
Alcaligenes faecalis | |
D/L-histidine | - |
Bacillus subtilis | |
D/L-histidine | - |
Citrobacter freundii | |
D/L-histidine | - |
Enterobacter cloacae | |
D/L-histidine | - |
Erwinia aroidea | |
D/L-histidine | - |
Escherichia coli | |
D/L-histidine | - |
Klebsiella aerogenes | |
D/L-histidine | - |
Kocuria rosea | |
D/L-histidine | - |
Lysinibacillus sphaericus | |
D/L-histidine | - |
Pseudomonas fluorescens | |
glycine | - |
Lysinibacillus sphaericus | |
glycine | - |
Pseudomonas fluorescens | |
L-cysteine | - |
Escherichia coli | |
L-cysteine | - |
Lysinibacillus sphaericus | |
L-cysteine | - |
Pseudomonas fluorescens | |
L-histidine | - |
Lysinibacillus sphaericus | |
L-serine | - |
Lysinibacillus sphaericus | |
L-serine | - |
Pseudomonas fluorescens | |
pyridoxal 5'-phosphate | high concentrations | Lysinibacillus sphaericus | |
Pyruvic acid | - |
Pseudomonas fluorescens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-carboxyhexanoyl-CoA + L-alanine | Alcaligenes faecalis | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Bacillus subtilis | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Escherichia coli | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Enterobacter cloacae | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Lysinibacillus sphaericus | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Kocuria rosea | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Pseudomonas fluorescens | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Klebsiella aerogenes | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Citrobacter freundii | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Erwinia aroidea | i.e. pimeloyl-CoA | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Alcaligenes faecalis | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Bacillus subtilis | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Escherichia coli | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Enterobacter cloacae | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Lysinibacillus sphaericus | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Kocuria rosea | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Pseudomonas fluorescens | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Klebsiella aerogenes | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Citrobacter freundii | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | Erwinia aroidea | reaction in biotin biosynthesis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Alcaligenes faecalis | - |
- |
- |
Bacillus subtilis | - |
- |
- |
Citrobacter freundii | - |
- |
- |
Enterobacter cloacae | - |
- |
- |
Erwinia aroidea | - |
- |
- |
Escherichia coli | - |
- |
- |
Klebsiella aerogenes | - |
- |
- |
Kocuria rosea | - |
- |
- |
Lysinibacillus sphaericus | - |
- |
- |
Pseudomonas fluorescens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Pseudomonas fluorescens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
crude cell-extracts from various organism | Alcaligenes faecalis |
additional information | - |
crude cell-extracts from various organism | Bacillus subtilis |
additional information | - |
crude cell-extracts from various organism | Escherichia coli |
additional information | - |
crude cell-extracts from various organism | Enterobacter cloacae |
additional information | - |
crude cell-extracts from various organism | Lysinibacillus sphaericus |
additional information | - |
crude cell-extracts from various organism | Kocuria rosea |
additional information | - |
crude cell-extracts from various organism | Pseudomonas fluorescens |
additional information | - |
crude cell-extracts from various organism | Klebsiella aerogenes |
additional information | - |
crude cell-extracts from various organism | Citrobacter freundii |
additional information | - |
crude cell-extracts from various organism | Erwinia aroidea |
0.00016 | - |
- |
Pseudomonas fluorescens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Alcaligenes faecalis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Bacillus subtilis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Escherichia coli | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Enterobacter cloacae | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Lysinibacillus sphaericus | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Kocuria rosea | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Pseudomonas fluorescens | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Klebsiella aerogenes | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Citrobacter freundii | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | i.e. pimeloyl-CoA | Erwinia aroidea | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | L-cysteine cannot replace L-alanine | Lysinibacillus sphaericus | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | L-cysteine cannot replace L-alanine | Kocuria rosea | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | L-cysteine cannot replace L-alanine | Pseudomonas fluorescens | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Alcaligenes faecalis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Bacillus subtilis | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Escherichia coli | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Enterobacter cloacae | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Lysinibacillus sphaericus | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Kocuria rosea | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Pseudomonas fluorescens | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Klebsiella aerogenes | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Citrobacter freundii | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? | |
6-carboxyhexanoyl-CoA + L-alanine | reaction in biotin biosynthesis | Erwinia aroidea | 8-amino-7-oxononanoate + CoA + CO2 | i.e. 7-oxo-8-amino-pelargonic acid | ? |
Synonyms | Comment | Organism |
---|---|---|
KAPA synthetase | - |
Alcaligenes faecalis |
KAPA synthetase | - |
Bacillus subtilis |
KAPA synthetase | - |
Escherichia coli |
KAPA synthetase | - |
Enterobacter cloacae |
KAPA synthetase | - |
Lysinibacillus sphaericus |
KAPA synthetase | - |
Kocuria rosea |
KAPA synthetase | - |
Pseudomonas fluorescens |
KAPA synthetase | - |
Klebsiella aerogenes |
KAPA synthetase | - |
Citrobacter freundii |
KAPA synthetase | - |
Erwinia aroidea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Alcaligenes faecalis | |
pyridoxal 5'-phosphate | - |
Bacillus subtilis | |
pyridoxal 5'-phosphate | - |
Escherichia coli | |
pyridoxal 5'-phosphate | - |
Enterobacter cloacae | |
pyridoxal 5'-phosphate | - |
Kocuria rosea | |
pyridoxal 5'-phosphate | - |
Pseudomonas fluorescens | |
pyridoxal 5'-phosphate | - |
Klebsiella aerogenes | |
pyridoxal 5'-phosphate | - |
Citrobacter freundii | |
pyridoxal 5'-phosphate | - |
Erwinia aroidea | |
pyridoxal 5'-phosphate | dependent on | Lysinibacillus sphaericus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.99 | - |
L-cysteine | - |
Lysinibacillus sphaericus | |
1.24 | - |
D-alanine | - |
Lysinibacillus sphaericus | |
1.5 | - |
L-serine | - |
Lysinibacillus sphaericus | |
3.33 | - |
glycine | - |
Lysinibacillus sphaericus | |
3.75 | - |
D-histidine | - |
Lysinibacillus sphaericus | |
5.6 | - |
L-histidine | - |
Lysinibacillus sphaericus |