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Literature summary for 2.3.1.48 extracted from

  • Attisano, L.; Lewis, P.N.
    Purification and characterization of two porcine liver nuclear histone acetyltransferases (1990), J. Biol. Chem., 265, 3949-3955.
    View publication on PubMed
Search for more literature for 2.3.1.48

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus enzyme forms I and II Sus scrofa 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid composition and of enzyme forms I and II are indistinguishable, specific antibodies are not cross-reactive Sus scrofa
40000
-
 1 * 50000 + 1 * 40000, enzyme form II, SDS-PAGE Sus scrofa
45000
-
 1 * 45000 + 1 * 62000, enzyme form I, SDS-PAGE Sus scrofa
50000
-
 1 * 50000 + 1 * 40000, enzyme form II, SDS-PAGE Sus scrofa
62000
-
 1 * 45000 + 1 * 62000, enzyme form I, SDS-PAGE Sus scrofa
110000
-
 enzyme forms I and II, gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 enzyme form type I and type II
-

Purification (Commentary)

Purification (Comment) Organism
enzyme forms I and II Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Sus scrofa CoA + acetylhistone
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 45000 + 1 * 62000, enzyme form I, SDS-PAGE Sus scrofa
dimer 1 * 50000 + 1 * 40000, enzyme form II, SDS-PAGE Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4 37
-
 Sus scrofa
37
-
 assay at Sus scrofa

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4 47 4-37°C: activity maximum, 47°C: 50% of activity maximum Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.8
-
 acetyl-CoA enzyme form type I Sus scrofa
0.8
-
 histone enzyme form type I Sus scrofa
12
-
 acetyl-CoA enzyme form type II Sus scrofa
12
-
 histone enzyme form type II Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Sus scrofa