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Literature summary for 2.3.1.48 extracted from

  • Herrera, J.E.; Bergel, M.; Yang, X.J.; Nakatani, Y.; Bustin, M.
    The histone acetyltransferase activity of human GCN5 and PCAF is stabilized by coenzymes (1997), J. Biol. Chem., 272, 27253-27258.
    View publication on PubMed

General Stability

General Stability Organism
acetyl-CoA stabilizes the enzyme form PCAF Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DNA acetylation of histone H1by the enzymes PCAF and GNC5 is inhibited in vivo by complexing of H1 with DNA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone Homo sapiens histone H1 is not acetylated in vivo CoA + acetylhistone
-
?
acetyl-CoA + histone Homo sapiens GCN5 histone H1 is not acetylated in vivo CoA + acetylhistone
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
GCN5
-
Homo sapiens
-
recombinant enzyme hPCAF, i.e. human p300/CBP associated factor
-
Homo sapiens GCN5
-
GCN5
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens CoA + acetylhistone
-
?
acetyl-CoA + histone histone H1 is not acetylated in vivo Homo sapiens CoA + acetylhistone
-
?
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens GCN5 CoA + acetylhistone
-
?
acetyl-CoA + histone histone H1 is not acetylated in vivo Homo sapiens GCN5 CoA + acetylhistone
-
?
acetyl-CoA + histone H1 histone H1 poor substrate Homo sapiens CoA + acetylhistone H1
-
?
acetyl-CoA + histone H1 acetylation of histone H1 only in vitro Homo sapiens CoA + acetylhistone H1
-
?
acetyl-CoA + histone H1 histone H1 poor substrate Homo sapiens GCN5 CoA + acetylhistone H1
-
?
acetyl-CoA + histone H1 acetylation of histone H1 only in vitro Homo sapiens GCN5 CoA + acetylhistone H1
-
?
acetyl-CoA + histone H4 histone H4 is the preferred substrate Homo sapiens CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4 histone H4 is the preferred substrate Homo sapiens GCN5 CoA + acetylhistone H4
-
?