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Literature summary for 2.3.1.48 extracted from

  • Champagne, N.; Bertos, N.R.; Pelletier, N.; Wang, A.H.; Vezmar, M.; Yang, Y.; Heng, H.H.; Yang, X.J.
    Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein (1999), J. Biol. Chem., 274, 28528-28536.
    View publication on PubMed
Search for more literature for 2.3.1.48

Cloned(Commentary)

Cloned (Comment) Organism
expression of MORF protein as FLAG-tagged protein in Sf9 insect cells via baculovirus infection, and as Gal4-fusion protein in 293T cells, amino acid sequence Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 MORF protein contains histone acetyltransferase, and transcription activating and repressing domains Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 MORF protein, i.e. monocytic leukemia zinc finger protein-related factor
-
Homo sapiens Q8WYB5 fragment EST clone of MORF protein, i.e. monocytic leukemia zinc finger protein-related factor
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from Sf9 insect cells via baculovirus infection, FLAG-tagged MORF protein Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine acetylation of lysine 5, 8, 12, and 16 of free histone H4 Homo sapiens
a
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine mechanisms Homo sapiens
a
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine MORF protein is also active as transcription factor Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
monocyte leukemic Homo sapiens
-
additional information ubiquitous expression of MORF protein in human tissue Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone calf thymus and HeLa cell histones Homo sapiens CoA + acetylhistone
-
 ?
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens CoA + acetylhistone
-
 ?
acetyl-CoA + histone H3
-
 Homo sapiens CoA + acetylhistone H3
-
 ?
acetyl-CoA + histone H4 histone H4 is the preferred substrate Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Homo sapiens
More enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 MORF protein, assay at Homo sapiens